姓名：李贞
职称职务：副教授，硕士生导师
学科专业：分析化学
研究领域： 稀土荧光纳米探针及生物成像
Email：zhenli@hubu.edu.cn
李贞博士，硕士生导师， 2011年获武汉大学理学学士学位，2016年获武汉大学分析化学专业理学博士学位。2017-2019年武汉大学生命科学学院微生物学博士后。2017年入选“中国博士后创新人才支持计划”，2019年入选湖北省“楚天学者计划-楚天学子”。近五年在JACS, Adv. Funct. Mater., Anal. Chem.等期刊发表SCI论文30余篇。
主要科研课题：
1．基于稀土纳米颗粒的NIR-IIb光动力治疗及疗效监测一体化平台，国家自然科学基金面上项目，2022.01－2025.12，主持人。
2．基于上转换荧光的可逆氧化还原探针的设计构建及应用，国家自然科学基金青年科学基金，2019.01-2021.12，主持人。
主要科研论文：
1. Zhen Li#, Caixia Wang#, Meng Zhang, Songjiao Li, Zhiqiang Mao, Zhihong Liu*. Activatable Luminescent Probes for Imaging Brain Diseases, Nano Today 2021, 39, 101239.
2. Meng Zhang, Zijun Wang, Caixia Wang, Yuting Wu, Zhen Li*, Zhihong Liu*. Visualizing Oxidative Stress Level for Timely Assessment of Ischemic Stroke via a Ratiometric NIR-II Luminescent Nanoprobe, ACS Nano 2021, 15, 11940-11952.
3. Qirong Wang#, Tao Liang#, Junjie Wu, Zhen Li*, Zhihong Liu. Dye-Sensitized Rare Earth-Doped Nanoparticles with Boosted NIR-IIb Emission for Dynamic Imaging of Vascular Network-Related Disorders, ACS Appl. Mater. Interfaces 2021, 13, 29303-29312.
4. Dan Song, Mengting Zhu, Siyu Chi, Lan Xia, Zhen Li*, Zhihong Liu*. Sensitizing the Luminescence of Lanthanide-Doped Nanoparticles over 1500 nm for High-Contrast and Deep Imaging of Brain Injury, Anal. Chem. 2021, 2021, 93, 7949-7957
5. Miaomiao Zuo, Qian Duan, Chenchen Li, Juan Ge, Qirong Wang, Zhen Li*, Zhihong Liu. A Versatile Strategy for Constructing Ratiometric Upconversion Luminescent Probe with Sensitized Emission of Energy Acceptor, Anal. Chem. 2021, 93, 5635-5643.
6. Tao Liang, Qirong Wang, Zhen Li*, Peipei Wang, Junjie Wu, Miaomiao Zuo, Zhihong Liu*. Removing the Obstacle of Dye-Sensitized Upconversion Luminescence in Aqueous Phase to Achieve High-Contrast Deep Imaging in Vivo, Adv. Funct. Mater. 2020, 30, 1910765.
7. Meng Zhang, Miaomiao Zuo, Caixia Wang, Zhen Li*, Qingyuan Cheng, Ju Huang, Zijun Wang, Zhihong Liu*. Monitoring Neuroinflammation with an HOCl-Activatable and Blood-Brain Barrier Permeable Upconversion Nanoprobe, Anal. Chem. 2020, 92, 5569-5576.
8. Zhen Li, Junjie Wu, Qirong Wang, Tao Liang, Juan Ge, Peipei Wang, Zhihong Liu*. A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging, iScience 2020, 23, 100962.
9. Songjiao Li, Dan Song, Weijing Huang, Zhen Li*, Zhihong Liu. In Situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-Infrared Emissive Fluorescent Probe, Anal. Chem. 2020, 92, 2802-2808.
10. Zhen Li, Tao Liang, Qirong Wang, Zhihong Liu*. Strategies for Constructing Upconversion Luminescence Nanoprobes to Improve Signal Contrast. Small 2020, 16, 1905084.
11. Dan Song, Siyu Chi, Xin Li, Caixia Wang, Zhen Li*, Zhihong Liu*. Upconversion System with Quantum Dots as Sensitizer: Improved Photoluminescence and PDT Efficiency, ACS Appl. Mater. Interfaces 2019, 11, 41100-41108.
12. Xiaoxue Ye#, Yunhui Xiang#, Qirong Wang, Zhen Li*, Zhihong Liu*. A Red Emissive Two-Photon Fluorescence Probe Based on Carbon Dots for Intracellular pH Detection, Small 2019, 15, 1901673
13. Tao Liang, Zhen Li*, Peipei Wang, Fangzhou Zhao, Jizhou Liu, Zhihong Liu*. Breaking Through the Signal-to-Background Limit of Upconversion Nanoprobes Using a Target-Modulated Sensitizing Switch. J. Am. Chem. Soc. 2018, 140, 14696-14703.
14. Yuping Han, Lin Shen, Zhen Li*, Zhihong Liu*, A Strategy to Facilitate the Assembly of DNA and Upconversion Nanoparticles for Biosensor Construction, Anal. Methods 2018, 10, 3933-3938.
15. Zhen Li, Tao Liang, Songwei Lv, Qinggeng Zhuang, Zhihong Liu*. J. Am. Chem. Soc. 2015, 137, 11179-11185.
16. Zhen Li, Songwei Lv, Yali Wang, Shiyu Chen, Zhihong Liu*. J. Am. Chem. Soc. 2015, 137, 3421-3427.
17. Zhen Li, Mengyuan He, Dangdang Xu, Zhihong Liu*. J. Photochem. Photobio. C: Photochemistry Reviews 2014, 18, 1-17.
